Comparison of facial function scores between groups demonstrated statistically worse outcomes for those who received corticosteroids as part of their initial treatment. The analysis of all available data on the primary outcome of change in the facial features (facial hair, facial fat, forehead wrinkles and nasal fold thickness) suggested that corticosteroids did not make a clinically significant difference in improvement.Of the 1128 patients in our study, 828 were randomized and 556 were randomly assigned to receive corticosteroids for one year. Although the overall number of patients being randomized to receive corticosteroid therapy in this study exceeds previous studies, the statistical power to detect a statistically significant outcome difference based on sample size was insufficient, best and safest bulking steroid. Furthermore, many patients did not complete the 12-week randomized phase, best and safest oral steroid. Therefore, it is premature to draw conclusions regarding the effectiveness of corticosteroids in this study population, although the overall rate of follow-up was high for all treatment groups.In these first studies of facial feminization, the number of patients who improved significantly has been very small, best and safe steroids. One-year results from a clinical trial in our lab demonstrate a trend of modest improvement within 12 weeks for facial hair or facial fat in healthy premenopausal women (32), best and safest testosterone steroid. More recently, a randomized, placebo-controlled study in the face-lift section of the annual dermatologic meeting in New Jersey demonstrated significant improvement in facial men and facial hair loss in women with mild-to-moderate acne treatment (17). The results of the latter trial, however, are subject to significant limitations, corticosteroids function. The study was restricted to women who received oral estrogen only and not testosterone. This restriction precludes the possibility that the increased skin elasticity of estrogen may be a factor in the improvement in facial men (17). The lack of a placebo group, and the relatively low sample size, limit the generalizability of this data to premenopausal women, best and safest anabolic steroid. The small number of acne patients in the study (n = 4) may also be attributable to the nature of the study. Although it is difficult to make a definitive conclusion, we think that our study reflects the best available evidence concerning the effect of hormonal therapy for face feminization.A number of investigators have suggested that changes in the genital features of premenopausal women may be secondary rather than primary to hormonal therapy for facial feminization in the face (8, 9, 12). It is not possible to make any definitive statements regarding this issue, because there is no controlled clinical trials addressing this issue, function corticosteroids.
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